為了維持基因的完整與穩定，細胞發展出各種由蛋白分子組成的DNA修復機制，研究團隊發現一個長鏈非編碼RNA會幫助招募蛋白分子，參與DNA的修復，同時會與RNA結合蛋白藉由液態-液態相分離形成凝聚體，提高修復效率。
The high frequency of DNA damage necessitates effective repair mechanisms. DNA damage repair involves various repair machineries. We recently uncovered a long non-coding RNA, which is essential for efficient recruitment of DNA repair factors to the sites of DNA double strand break. Moreover, its associated RNA processing factors degrade the transcripts generated by double strand breaks at DNA lesions, facilitating the turnover of DNA repair factors. Furthermore, this non-coding RNA forms liquid-like droplets with an RNA binding protein. RNA and protein co-phase separation appears to promote DNA repair. Our studies reveal an important role of RNA in DNA damage repair.
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