東亞地區肺癌的特點是從未吸煙的病人、早期發病和EGFR基因突變的比例很高。以臺灣病人進行深度蛋白基因體學之前瞻性研究，闡釋這些獨特的疾病分子表徵，以早期、女性、非吸煙的肺腺癌為主。分析基因蛋白體和磷酸化蛋白質體統計出不同的分子屬性和腫瘤進展的標誌；突變特徵分析出年輕女性中APOBEC突變特徵的發生頻率較高，而環境致癌物突變特徵在年長女性中較高比例顯著。蛋白質體學提供新分類法，可區分早期EGFR突變患者的臨床特徵。
The team completed East Asia’s first large-scale data of the deep proteogenomics of one hundred lung cancer patients, and analyzed the causes and new subtypes of non-smoking lung cancer among East Asia. It was published in the top international journal Cell in July 2020 and won the cover story of the issue. This is also the first time that the American Clinical Proteomic Tumor Analysis Consortium (CPTAC) and the International Team (Taiwan) have worked together to unveil the biology of lung cancer in Taiwan and the United States with proteogenomics.