Genetic information in a eukaryotic cell is stored in its chromatin, a composite of DNA and proteins, densely packed within the nucleus. The nucleus also contains various subnuclear compartments, whose spatiotemporal coordination within the chromatin is known to be one of crucial factors in determining gene expression. Meanwhile, in a living cell, other subnuclear molecules, such as enzymes, act to facilitate cellular functions. Although it is speculated that these acting molecules may mechanically perturb the chromatin state and affect the fluctuating motion of subnuclear compartments, this effect remained elusive. In the displayed work, computer simulations were performed to study this effect from a physical perspective.
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